2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid

2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid - Names and Identifiers

Name	2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid
Synonyms	EOSIN Y Bromeosin Eosin acid Bromoeosin Eosine acid Red No. 223 BROMO ACID J Japan Red 223 Solvent Red 43 BRONZE BROMO ES Eosin Yellowish BROMOFLUORESCEIN Japan Red No. 223 EOSIN YELLOWISH Y D and C Red No. 21 C.I. Solvent Red 43 EOSIN Y DISODIUM SALT Eosin Y spirit soluble BROMO ACID J TS, XL, OR XX EOSIN YELLOWISH WATER-SOLUBLE 2',4',5',7'-Tetrabromofluorescein Fluorescein, 2',4',5',7'-tetrabromo- Fluorescein, 2',4',5',7'-tetrabromo- (VAN) 4-19-00-02917 (Beilstein Handbook Reference) 2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid 3,6-Dihydroxy-2,4,5,7-tetrabromospiro(xanthene-9,3'-phthalide) 2-(2,4,5,7-tetrabromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxo-3H-xanthen-9-yl)benzoate 2',4',5',7'-tetrabromo-3',6'-dihydroxy-3H-spiro[2-benzofuran-1,9'-xanthen]-3-one 2',4',5',7'-Tetrabromo-3',6'-dihydroxyspiro(isobenzofuran-1(3H),9- '-(9H)xanthen)-3-one Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy- Spiro(isobenzofuran-1(3H),9'-(9H)-xanthen)-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-
CAS	15086-94-9
EINECS	239-138-3
InChI	InChI=1/C20H10Br4O5/c21-11-5-9-13(7-3-1-2-4-8(7)20(27)28)10-6-12(22)17(26)15(24)19(10)29-18(9)14(23)16(11)25/h1-6,13,25-26H,(H,27,28)
InChIKey	DBZJJPROPLPMSN-UHFFFAOYSA-N

2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid - Physico-chemical Properties

Molecular Formula	C20H8Br4O5
Molar Mass	647.89
Density	1.02g/mLat 20°C
Melting Point	300 °C
Boling Point	640.3±55.0 °C(Predicted)
Solubility	H2O: 0.1g/mL, dark red
Appearance	Orange red crystalline powder
Color	White to Light yellow to Red
pKa	6.97±0.20(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Stability	Stable. Incompatible with strong oxidizing agents.
Sensitive	Easily absorbing moisture
Refractive Index	1.5000 (estimate)
MDL	MFCD00036189
Use	Eosin Y is a xanthene dye used for differential staining of linked tissues and cytoplasm. In histopathology, it is used after hematoxylin and before methyl blue as a re-staining. It can also be used as a background stain to provide contrast for the nucleus. Eosin Y is a reagent for the preparation of a nigromycin-eosin (NE) stain and is used for alginic acid visualization in the hematoxylin-eosin (H & E) staining technique.

2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36 - Irritating to the eyes
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S24/25 - Avoid contact with skin and eyes.
UN IDs	UN 1170 3/PG 2
WGK Germany	3
RTECS	LM5850000
HS Code	32041919

2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid - Reference

Reference

1. [IF=7.328] Na Huang et al."Preparation and evaluation of squid ink polysaccharide-chitosan as a wound-healing sponge."Mat Sci Eng C-Mater. 2018 Jan;82:354
2. [IF=1.851] Yongheng Bai et al."Anti‑fibrotic effect of Sedum sarmentosum Bunge extract in kidneys via the hedgehog signaling pathway."Mol Med Rep. 2017 Jul;16(1):737-745
3. [IF=3.407] Ya-Ping Jiang et al."Protective effects of Salidroside on spermatogenesis in streptozotocin induced type-1 diabetic male mice by inhibiting oxidative stress mediated blood-testis barrier damage."Chem-Biol Interact. 2020 Jan;315:108869

2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid - Wavelength

λmax 524 nm

Last Update：2023-08-16 21:32:38

2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid - Reference Information

color index	45380:2
(IARC) carcinogen classification	3 (Vol. 15, Sup 7) 1987
EPA chemical information	Information provided by: ofmpub.epa.gov (external link)
overview	according to the 2015 edition of "cosmetic safety technical specification", brominated fluorescein cosmetic dyes include 4 ',5'-dibromofluorescein, 2 ',4',5 ',7'-tetrabromofluorescein, 2 ',4',5 ',7'-tetrabromo-4, 7-dichlorofluorescein, 2 ',4',5 ',7'-Tetrabromo-4, 5,6, 7-tetrachlorofluorescein. These four dyes and their respective disodium salt dyes or lakes are allowed to be used for coloring cosmetics. Among them, 2 ',4',5 ',7'-tetrabromofluorescein is solvent red 43, also known as 2 ',4',5 ',7'-tetrabromo-3', 6 '-dihydroxyspiro [isopropylfuran -1(3H),9'(9H)-ton]-3-one, it is a dye and pigment
preparation	solvent red 43 is prepared as follows: add 61.0g of sodium hypochlorite solution (10%,86mmol) into a 250mL four-mouth flask, place an ice water bath externally, start stirring, add about 36g of water, 24.3g of 32% liquid alkali, slowly drip 13.9g of bromine (99%,86mmol) after the material temperature reaches 0~5 ℃, control the reaction temperature below 15°C. Determine the content (about 20% effective bromine) and reserve. Add 250g acetic acid into a 500mL four-mouth flask, start stirring, add 13.6g fluorescein (97.5%,40mmol), raise the temperature to 50~60 ℃, and stir quickly (300~400rpm) for 30min. The temperature was reduced to 25-30 ℃, and 134.0g of the above sodium hypobromite solution (20%,168mmol) was slowly added dropwise within 3-4 hours, during which the reaction temperature was controlled at 25-30 ℃. Heat preservation and stirring for 2 hours, sampling for liquid phase detection of bromination endpoint. Add appropriate amount of sodium bisulfite to eliminate residual hypobromous acid. Cooling to 15 ℃, suction filtration, crude filter cake. The crude filter cake is evenly beaten and filtered in about 100mL dilute hydrochloric acid aqueous solution (1 500), and desalting is repeated 3 times. The filter cake was dried at 100 ℃ to obtain 25.0g of light pink target product solvent red 43(HPLC purity 97.8%, content 97.8%,37.7mmol) with 94.3% yield.
Use	Biochemical research Biological stain. Adsorption indicator, verification of fluoride ions, quantitative analysis and titration of bromide ions and iodine ions. Tianqing B according to red reserve liquid preparation.

Last Update：2024-04-09 19:05:10

2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid

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2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid

2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid

2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid

CAS: 15086-94-9

Molecular Formula: C20H8Br4O5

2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid - Names and Identifiers

2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid - Physico-chemical Properties

2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid - Risk and Safety

2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid - Reference

2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid - Wavelength

2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid - Reference Information

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2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid

CAS: 15086-94-9

Molecular Formula: C20H8Br4O5

2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid - Names and Identifiers

2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid - Physico-chemical Properties

2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid - Risk and Safety

2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid - Reference

2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid - Wavelength

2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid - Reference Information

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2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid